Calcium channel blockers for potential impaired fetal growth (Cochrane Review)

A substantive amendment to this systematic review was last made on 13 January 1995. Cochrane reviews are regularly checked and updated if necessary.

Background: Calcium channel blockers may increase the blood flow to the fetus or may improve fetal-placental cellular energy generation. This could enhance fetal growth.

Objectives: The objectives of this review were to assess the effects of calcium channel blockers on fetal growth and neonatal morbidity and mortality in pregnancies where impaired fetal growth is suspected.

Search strategy: We searched the Cochrane Pregnancy and Childbirth Group trials register (November 2002).

Selection criteria: Acceptably controlled trials of calcium channel blockers in women with potential impaired fetal growth.

Data collection and analysis: Eligibility and trial quality were assessed.

Main results: One study of 100 women (all smokers) was included. Mean birth weight was significantly higher in women receiving flunarizine compared to the control group. No other significant differences were found.

Reviewers' conclusions: There is not enough evidence to evaluate the use of calcium channel blockers for impaired fetal growth. The apparent beneficial effect of calcium channel blockers on birthweight warrants further investigation.

Citation: Say L, Gülmezoglu AM, Hofmeyr GJ. Calcium channel blockers for potential impaired fetal growth (Cochrane Review). In: The Cochrane Library, Issue 3, 2003. Oxford: Update Software.

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This is an abstract of a regularly updated, systematic review prepared and maintained by the Cochrane Collaboration. The full text of the review is available in The Cochrane Library (ISSN 1464-780X).

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