Domiciliary oxygen for interstitial lung disease (Cochrane Review)

Crockett AJ, Cranston JM, Antic N

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A substantive amendment to this systematic review was last made on 22 May 2001. Cochrane reviews are regularly checked and updated if necessary.
Background: Retrospective survival data have suggested poor effectiveness of oxygen therapy in patients with interstitial lung disease (ILD).
Objectives: To determine the effect of domiciliary oxygen therapy on survival and quality of life in patients with a diagnosis of ILD and hypoxaemia.
Search strategy: Randomized Controlled Trials (RCTs) were identified using the Cochrane Airways Group register and the search terms: (home OR domiciliary AND oxygen AND (Interstitial lung disease OR ILD OR pulmonary fibrosis OR IPF)).
Selection criteria: Any randomized controlled trial (RCT) in adult patients with hypoxaemia and ILD that compared long term domiciliary or home oxygen therapy with a control group.
Data collection and analysis: Only one unpublished RCT was identified.
Main results: Only one trial was identified. Mortality for both the oxygen treated and control groups was approximately 91% after 3 years (Peto odds ratio 0.99, 95% confidence intervals 0.16,6.26). The effect of oxygen therapy on quality of life and physiological parameters was not reported.
Reviewers' conclusions: The assumption that home oxygen therapy has a beneficial survival effect in patients with ILD has not been demonstrated in the single RCT identified.
Citation: Crockett AJ, Cranston JM, Antic N. Domiciliary oxygen for interstitial lung disease (Cochrane Review). In: The Cochrane Library, Issue 3, 2003. Oxford: Update Software.

This is an abstract of a regularly updated, systematic review prepared and maintained by the Cochrane Collaboration. The full text of the review is available in The Cochrane Library (ISSN 1464-780X).
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File Reference: AB002883.htm