Radiotherapy for early breast cancer (Cochrane Review)

A substantive amendment to this systematic review was last made on 17 February 2002. Cochrane reviews are regularly checked and updated if necessary.

Background: The long-term effects of radiotherapy on mortality from breast cancer and other causes remain uncertain.

Objectives: In this report the Early Breast Cancer Trialists' Collaborative Group present their systematic overview of treatment with radiotherapy.

Search strategy: Trial identification procedures for the EBCTCG overviews have been described elsewhere. See under "EBCTCG" in the Breast Cancer Group module.

Selection criteria: A meta-analysis was done of 10-year and 20-year results from 40 unconfounded randomised trials of radiotherapy for early breast cancer. Radiotherapy fields generally included not only chest wall (or breast) but also axillary, supraclavicular, and internal mammary nodes.

Data collection and analysis: Data collection involved central review of individual patient data on recurrence and cause-specific mortality from 20,000 women.

Main results: A reduction of approximately two-thirds in local recurrence was seen in all trials, largely independent of the type of patient or type of radiotherapy (8·8% vs 27·2% local recurrence by year 10). Hence, to assess effects on breast cancer mortality of substantially better local control, results from all trials were combined. Breast cancer mortality was reduced (2p=0·0001) but other, particularly vascular, mortality was increased (2p=0·0003), and overall 20-year survival was 37·1% with radiotherapy versus 35·9% control (2p=0·06). There was little effect on early deaths, but logrank analyses of later deaths indicate that, on average after year 2, radiotherapy reduced annual mortality rates from breast cancer by 13·2% (SE 2·5) but increased those from other causes by 21·2% (SE 5·4). Nodal status, age, and decade of follow-up strongly affected the ratio of breast cancer mortality to other mortality, and hence affected the ratio of absolute benefit to absolute hazard from these proportional changes in mortality.

Reviewers' conclusions: Radiotherapy regimens able to produce the two-thirds reduction in local recurrence seen in these trials, but without long-term hazard, would be expected to produce an absolute increase in 20-year survival of about 2-4% (except for women at particularly low risk of local recurrence). The average hazard seen in these trials would, however, reduce this 20-year survival benefit in young women and reverse it in older women.

Citation: Early Breast Cancer Trialists' Collaborative Group. Radiotherapy for early breast cancer (Cochrane Review). In: The Cochrane Library, Issue 3, 2003. Oxford: Update Software.

---

This is an abstract of a regularly updated, systematic review prepared and maintained by the Cochrane Collaboration. The full text of the review is available in The Cochrane Library (ISSN 1464-780X).

The Cochrane Library is designed and produced by Update Software Ltd.

Update Software Ltd, Summertown Pavilion, Middle Way, Oxford OX2 7LG, UK
(Tel:+44 1865 513902; Fax:+44 1865 516918)

File Reference: AB003647.htm